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Literature summary for 2.7.11.2 extracted from

  • Zhang, M.; Zhao, Y.; Li, Z.; Wang, C.
    Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis (2018), Biochem. Biophys. Res. Commun., 495, 582-586 .
    View publication on PubMed
Search for more literature for 2.7.11.2

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [pyruvate dehydrogenase (acetyl-transferring)] Homo sapiens
-
 ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?
ATP + [pyruvate dehydrogenase (acetyl-transferring)] Mus musculus
-
 ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus Q16654
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
hepatoma cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [pyruvate dehydrogenase (acetyl-transferring)]
-
 Homo sapiens ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?
ATP + [pyruvate dehydrogenase (acetyl-transferring)]
-
 Mus musculus ADP + [pyruvate dehydrogenase (acetyl-transferring)] phosphate
-
 ?

Synonyms

Synonyms Comment Organism
PDK4
-
 Homo sapiens
PDK4
-
 Mus musculus
pyruvate dehydrogenase kinase 4
-
 Homo sapiens
pyruvate dehydrogenase kinase 4
-
 Mus musculus

Expression

Organism Comment Expression
Homo sapiens hepatic enzyme levels are highly induced in human patients with non-alcoholic steatohepatitis as well as in hepatocytes treated with oleic acid up
Mus musculus hepatic enzyme levels are highly induced in methionine and choline deficient diet fed mice up

General Information

General Information Comment Organism
malfunction enzyme-deficiency dramatically reduces the expression of genes related to fatty acid uptake, synthesis and gluconeogenesis Homo sapiens
malfunction enzyme-deficiency dramatically reduces the expression of genes related to fatty acid uptake, synthesis and gluconeogenesis. Enzyme deficiency ameliorates the hepatic steatosis significantly in nonalcoholic steatohepatitis mice Mus musculus
physiological function the enzyme potentially contributes to the hepatic steatosis in nonalcoholic steatohepatitis via regulating several signaling pathway Homo sapiens
physiological function the enzyme potentially contributes to the hepatic steatosis in nonalcoholic steatohepatitis via regulating several signaling pathway Mus musculus